Calcium 2-hydroxypropanoate (pentahydrate)

Calcium 2-hydroxypropanoate (pentahydrate) is a hydroxycarboxylic acid receptor 1 (HCAR1) activator and an epigenetic modulator inducing lysine residues lactylation. Calcium 2-hydroxypropanoate (pentahydrate) is a glycolysis end-product, bridging the gap between glycolysis and oxidative phosphorylation. Calcium 2-hydroxypropanoate (pentahydrate) is an oncometabolite and has immune protective role of lactate in anti-tumor immunity[1][2].

Product Specifications

CAS Number

[5743-47-5]

UNSPSC

12352200

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cancer; Metabolic Disease; Inflammation/Immunology

Concentration

10mM

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C(C)O)O.[Ca].O.[0.5].[2.5]

Molecular Formula

C3H6O3.0.5Ca.2.5H2O

Molecular Weight

155.17

Precautions

H302, H315, H319, H335

References & Citations

[1]Lucia Longhitano, et al. Lactate Rewrites the Metabolic Reprogramming of Uveal Melanoma Cells and Induces Quiescence Phenotype. Int J Mol Sci. 2022 Dec 20;24 (1) :24. |[2]Qiang Feng, et al. Lactate increases stemness of CD8 + T cells to augment anti-tumor immunity. Nat Commun. 2022 Sep 6;13 (1) :4981.