AZ7550 Mesylate (Standard)

AZ7550 Mesylate (Standard) is the analytical standard of AZ7550 Mesylate. This product is intended for research and analytical applications. AZ7550 Mesylate is an active metabolite of AZD9291 and inhibits the activity of IGF1R with an IC50 of 1.6 μM.

Product Specifications

CAS Number

[2319837-99-3]

Product Name Alternative

AZ7550 trimesylate salt (Standard)

UNSPSC

12352005

Target

Drug Metabolite; EGFR; IGF-1R; Reference Standards

Related Pathways

JAK/STAT Signaling; Metabolic Enzyme/Protease; Others; Protein Tyrosine Kinase/RTK

Field of Research

Cancer; Endocrinology

Smiles

CN1C=C(C2=NC(NC3=CC(NC(C=C)=O)=C(N(CCNC)C)C=C3OC)=NC=C2)C4=CC=CC=C41.O=S(O)(C)=O.O=S(O)(C)=O.O=S(O)(C)=O

Molecular Formula

C30H43N7O11S3

Molecular Weight

773.90

References & Citations

[1]Finlay MR, et al. Discovery of a potent and selective EGFR inhibitor (AZD9291) of both sensitizing and T790M resistance mutations that spares the wild type form of the receptor. J Med Chem. 2014 Oct 23;57 (20) :8249-67.