Sclerostin Antibody / SOST
Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease.
Product Specifications
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 1:25, Western blot: 1:500-1:2000
UniProt
Q9BQB4
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
A portion of amino acids 12-42 from the human protein was used as the immunogen for the Sclerostin antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
IHC-P, WB
Purity
Antigen affinity purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the Sclerostin antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This Sclerostin antibody is available for research use only.
Storage Conditions
Aliquot the Sclerostin antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Image Legend
Western blot testing of human 1) kidney and 2) liver lysate with Sclerostin antibody. Predicted molecular weight ~24 kDa.
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