Dapsone-15N2

Dapsone-15N2 (4,4′-Diaminodiphenyl sulfone-15N2) is 15N labeled Dapsone. Dapsone (4,4′-Diaminodiphenyl sulfone) is an orally active and blood-brain penetrant sulfonamide antibiotic with bacteriostatic, antimycobacterial and antiprotozoal activities[1]. Dapsone?exerts effective antileprosy activity?and inhibits folate synthesis in cell extracts of?M. leprae. Dapsone is used for dermatologic disorder research, including leprosy, dermatitis herpetiformis, acne vulgaris et al[2][3].

Product Specifications

CAS Number

[287476-19-1]

Product Name Alternative

4,4′-Diaminodiphenyl sulfone-15N2; DDS-15N2

UNSPSC

12352005

Target

Antibiotic; Bacterial; Isotope-Labeled Compounds; Parasite; Reactive Oxygen Species (ROS)

Related Pathways

Anti-infection; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Others

Applications

COVID-19-immunoregulation

Field of Research

Infection; Inflammation/Immunology

Smiles

O=S(C1=CC=C(C=C1)[15NH2])(C2=CC=C(C=C2)[15NH2])=O

Molecular Formula

C12H12 15N2O2S

Molecular Weight

250.29

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Y I Zhu, et al. Dapsone and sulfones in dermatology: overview and update. J Am Acad Dermatol|[3]Dapsone, Drug.com|[4]D Voeller, et al. Interaction of Pneumocystis carinii dihydropteroate synthase with sulfonamides and diaminodiphenyl sulfone (dapsone) .J Infect Dis. 1994 Feb;169 (2) :456-9.|[5]Esther Moreno, et al. Evaluation of Skin Permeation and Retention of Topical Dapsone in Murine Cutaneous Leishmaniasis Lesions.Pharmaceutics. 2019 Nov 13;11 (11) :607.

Shipping Conditions

Room temperature

Scientific Category

Isotope-Labeled Compounds

Clinical Information

No Development Reported

Curated Selection

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