Minoxidil (hydrochloride)

Minoxidil (U10858) hydrochloride is an ATP-sensitive potassium (KATP) channel opener, a potent oral antihypertensive agent and a peripheral vasodilator that promotes vasodilation also affects hair growth. Minoxidil hydrochloride is also a potent inhibitor of soybean lipoxygenaseare with an IC50 of 20 μM[1][2][3].

Product Specifications

CAS Number

[69935-18-8]

Product Name Alternative

U10858 (hydrochloride)

UNSPSC

12352005

Target

Endogenous Metabolite; Potassium Channel

Related Pathways

Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease

Field of Research

Cardiovascular Disease

Smiles

N=C1N=C(N2CCCCC2)C=C(N1O)N.Cl

Molecular Formula

C9H16ClN5O

Molecular Weight

245.71

References & Citations

[1]Hadjipavlou-Litina D, et al. Synthesis and evaluation of the antioxidative potential of minoxidil-polyamine conjugates. Biochimie. 2013 Jul;95 (7) :1437-49.|[2]Davies GC, et al. Novel and established potassium channel openers stimulate hair growth in vitro: implications for their modes of action in hair follicles. J Invest Dermatol. 2005 Apr;124 (4) :686-94. |[3]Cohen RL, et al. Direct effects of minoxidil on epidermal cells in culture. J Invest Dermatol. 1984 Jan;82 (1) :90-3.