Liothyronine-d4

Liothyronine-d4 (Triiodothyronine-d4) is the deuterium labeled Liothyronine (HY-A0070A) . Liothyronine is an active form of thyroid hormone. Liothyronine binds to thyroid hormone receptors TRα and TRβ with vs of 2.33 and 2.29 nM for hTRα and hTRβ, respectively. Liothyronine also binds to PVR and blocks the interaction of TIGIT/PVR[1][2][3].

Product Specifications

Product Name Alternative

Triiodothyronine-d4; 3,3',5-Triiodo-L-thyronine-d4; T3-d4

UNSPSC

12352101

Target

Endogenous Metabolite; Isotope-Labeled Compounds; Thyroid Hormone Receptor

Related Pathways

Metabolic Enzyme/Protease; Others; Vitamin D Related/Nuclear Receptor

Field of Research

Cancer; Endocrinology

Smiles

O=C(O[2H])[C@H](CC1=CC(I)=C(C(I)=C1)OC2=CC=C(O[2H])C(I)=C2)N([2H])[2H]

Molecular Formula

C15H8D4I3NO4

Molecular Weight

655.00

References & Citations

[1]Lin KH, et al. Stimulation of proliferation by 3,3',5-triiodo-L-thyronine in poorly differentiated human hepatocarcinoma cells overexpressing beta 1 thyroid hormone receptor. Cancer Lett. 1994 Oct 14;85 (2) :189-94. |[2]Bhat MK, et al. Conformational changes of human beta 1 thyroid hormone receptor induced by binding of 3,3',5-triiodo-L-thyronine. Biochem Biophys Res Commun. 1993 Aug 31;195 (1) :385-92. |[3]Hiroaki Shiohara, et al. Discovery of novel indane derivatives as liver-selective thyroid hormone receptor β (TRβ) agonists for the treatment of dyslipidemia. Bioorg Med Chem. 2012 Jun 1;20 (11) :3622-34.