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SB-247853

SB-247853 is a highly specific 5-HT2c receptor antagonist. SB-247853 induces orthostatic intolerance during head-up tilting. SB-247853 can be used in the research of cardiovascular diseases[1].

Product Specifications

CAS Number

200711-10-0

UNSPSC

12352005

Hazard Statement

H315-H319-H332-H335

Target

5-HT Receptor

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Smiles

O=C(N1CCC2=C1C=C(C(F)(F)F)C(C)=C2)NC3=CC=C(OCC4=NC=CC=C4)N=C3

Molecular Formula

C22H19F3N4O2

Molecular Weight

428.41

Precautions

P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362-P403+P233-P405-P501

References & Citations

[1]Theis J G, et al. Orthostatic intolerance induced by the 5‐HT2C antagonist SB‐247853 in healthy volunteers during head‐up tilting. Clinical Pharmacology & Therapeutics, 2005, 77 (2) : P66-P66.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

Phase 1

Isoform

5-HT2 Receptor

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