Anle138b
Synuclein aggregation inhibitor
Product Specifications
Background
Anle138b is an oligomeric aggregation inhibitor that inhibits the formation of pathological prion protein (PrPSc) and α-synuclein aggregates in vitro. Anle138b prevents accumulation of PrPSc in the brain and the spleen. Anle138b exhibits neuroprotective effects in a Parkinson's disease mouse model and improves motor performance in an α-synucleinopathy model.
CAS Number
882697-00-9
Product Name Alternative
3- (1,3-Benzodioxol-5-yl) -5- (3-bromophenyl) -1H-pyrazole, 5- (1,3-Benzodioxol-5-yl) -3- (3-bromophenyl) -1H-pyrazole, Anle 138b, CID 44608289
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Neuroscience | Neurodegeneration | Parkinson's Disease | Synuclein
Purity
>98% (HPLC) ; NMR (Conforms)
Weight
0.005
Format
White powder
Solubility
May be dissolved in DMSO (15 mg/ml, warm)
Molecular Formula
C16H11BrN2O2
Molecular Weight
343.2
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Wagner J. et al. (2013) Acta Neuropathol. 125 (6): 795-813.
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