NSD2-PWWP1-IN-6
NSD2-PWWP1-IN-6 (Compound 16) is an effective NSD2-PWWP1 inhibitor with a Kd value of 30 nM. NSD2-PWWP1-IN-6 competitively blocks the recognition of H3K36me2 and DNA by NSD2-PWWP1, thereby weakening its binding ability to nucleosomes. NSD2-PWWP1-IN-6 can be used for cancer research[1].
Product Specifications
CAS Number
[106664-01-1]
UNSPSC
12352005
Target
Histone Methyltransferase
Related Pathways
Epigenetics
Field of Research
Cancer
Smiles
O=C1C2=CC=CC=C2[Se]N1C3=C(OC)C=CC=C3
Molecular Formula
C14H11NO2Se
Molecular Weight
304.20
References & Citations
[1]Huang Y, et al. Fragment-Based Screening of NSD2-PWWP1 Identifies Novel Covalent Allosteric Ligands That Diminish Methyllysine and DNA Binding Abilities of NSD2. J Med Chem. 2025 Dec 11;68 (23) :24953-24967.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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