RNF220 (NM_018150) Human Recombinant Protein
Product Specifications
Background
E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of SIN3B (By similarity) . Independently of its E3 ligase activity, acts as a CTNNB1 stabilizer through USP7-mediated deubiquitination of CTNNB1 promoting Wnt signaling (PubMed:25266658) .[UniProtKB/Swiss-Prot Function]
Overview
Recombinant protein of human ring finger protein 220 (RNF220)
Synonyms
C1orf164
Gene ID
55182
UniProt
Q5VTB9
Accession Number mRNA
NM_018150
Chromosomal Location
1p34.1
Expression System
HEK293T
Tag
C-Myc/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome
Molecular Weight
62.6 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
RNF220
Species
Human
Protein ID
NP_060620
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/55182
Uniprot URL
https://www.uniprot.org/uniprot/Q5VTB9
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_018150
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_060620
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