CC-11
CC-11 is an orally active small molecule drug conjugate (SMDC) that links the PI3K/mTOR inhibitor with the extracellular heat shock protein 90 (EHSP90) targeting ligand through a cleavable linker. CC-11 exhibits strong HSP90 binding activity (IC50 = 15 nM) and inhibits PI3Kα kinase activity (IC50 = 0.54 nM) . CC-11 has anti-proliferative activity against colon cancer cells. CC-11 shows significant efficacy in the HCT-116 xenograft tumor model. CC-11 can be used for research on colon cancer[1].
Product Specifications
CAS Number
[3079942-94-9]
UNSPSC
12352005
Target
Akt; HSP; mTOR; PI3K
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; PI3K/Akt/mTOR
Field of Research
Cancer
Smiles
Molecular Formula
C52H54F2N12O10S
Molecular Weight
1077.12
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HSP90; PI3Kα
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