CC-11
CC-11 is an orally active small molecule drug conjugate (SMDC) that links the PI3K/mTOR inhibitor with the extracellular heat shock protein 90 (EHSP90) targeting ligand through a cleavable linker. CC-11 exhibits strong HSP90 binding activity (IC50 = 15 nM) and inhibits PI3Kα kinase activity (IC50 = 0.54 nM) . CC-11 has anti-proliferative activity against colon cancer cells. CC-11 shows significant efficacy in the HCT-116 xenograft tumor model. CC-11 can be used for research on colon cancer[1].
Product Specifications
CAS Number
3079942-94-9
UNSPSC
12352005
Target
Akt; HSP; mTOR; PI3K
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; PI3K/Akt/mTOR
Field of Research
Cancer
Smiles
CC(C1=CC(C(N2C3=CC=C(NC(CCC(NCC(OC4CCCN(C4)CCCN5C=C(N=N5)C6=CN=C7N6N=C(C=C7)C8=CC(NS(C9=CC=C(F)C=C9F)(=O)=O)=C(N=C8)OC)=O)=O)=O)C=C3CC2)=O)=C(C=C1O)O)C
Molecular Formula
C52H54F2N12O10S
Molecular Weight
1077.12
References & Citations
[1]Wang Z, et al. Development of PI3K/mTOR-HSP90 ligand conjugates for improved colorectal cancer therapy. Eur J Med Chem. 2026 Jan 15;302 (Pt 2) :118286.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HSP90; PI3Kα
Frequently Asked Questions
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