Apoptosis inducer 51

Apoptosis inducer 51 (Compound 5d) is an apoptosis inducer. Apoptosis inducer 51 exhibits strong inhibitory activity against MDA-MB-231 cells. Apoptosis inducer 51 inhibits cell invasion and migration, induces G2/M phase cell cycle arrest and cell apoptosis. Apoptosis inducer 51 causes DNA damage, ROS burst and mitochondrial membrane potential (MMP) collapse. Apoptosis inducer 51 can be used for the study of triple-negative breast cancer.

Product Specifications

UNSPSC

12352005

Target

Apoptosis; DNA/RNA Synthesis; Reactive Oxygen Species (ROS)

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Field of Research

Cancer

Smiles

[H][C@@]12CC[C@]3([H])[C@]([C@@]1(C)CC[C@H](OC(CCCNC(CCCC4=CC=C(N(CCCl)CCCl)C=C4)=O)=O)C2)([H])CC([C@]5(C)[C@H]6[C@H](C)[C@]7(OC[C@H](C)CC7)O[C@H]6C[C@]53[H])=O

Molecular Formula

C45H66Cl2N2O6

Molecular Weight

801.92

References & Citations

[1]Su W, et al. Hecogenin nitrogen mustard hybrids with improved anti-breast cancer activity: Design, synthesis, and biological evaluation. Bioorg Chem. 2025 Oct;165:109032.