MKK7-JNK activator 1

MKK7-JNK activator 1 (Compound 10) is a MKK7-JNK pathway activator. MKK7-JNK activator 1 effectively inhibits the proliferation and migration of MDA-MB-468 cells, induces G2/M phase arrest and caspase -dependent apoptosis (independent of ROS production) . MKK7-JNK activator 1 significantly increases the levels of p-MKK7 and p-JNK, but does not affect p-ERK or p-p38. MKK7-JNK activator 1 can be used for the study of triple-negative breast cancer (TNBC) [1].

Product Specifications

CAS Number

[3100092-62-1]

UNSPSC

12352005

Target

Apoptosis; Caspase; JNK; p38 MAPK

Related Pathways

Apoptosis; MAPK/ERK Pathway

Field of Research

Cancer

Smiles

CC1=NC2=C(OCC3=CC=CC(I)=C3)C(Br)=CC(Br)=C2C=C1

Molecular Formula

C17H12Br2INO

Molecular Weight

533.00

References & Citations

[1]Ma L, et al. Synthesis and evaluation of 8- (benzyloxy) -5,7-dibromo-2-methylquinoline derivatives as inducers of apoptosis in triple-negative breast cancer MDA-MB-468 cells via MKK7-JNK pathway activation. Bioorg Chem. 2025 Oct 17;166:109117.