5-HT7R antagonist 5

5-HT7R antagonist 5 (Compound (R) -4) is a 5-HT7AR antagonist, with a Ki of 46.4 nM. 5-HT7R antagonist 5 shows anticancer effects against prostate cancer[1].

Product Specifications

UNSPSC

12352005

Target

5-HT Receptor

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Cancer

Smiles

CN1[C@@]2([H])C3=C(C(C(SC(N)=N4)=C4C=C5)=C5C2)C=CC=C3CC1

Molecular Formula

C18H17N3S

Molecular Weight

307.41

References & Citations

[1]Okpattah D, et al. Synthesis and evaluation of aporphinoid 5-HT7AR ligands as inhibitors of PC3 prostate cancer cell growth. Bioorg Med Chem Lett. 2025 Dec 1;128:130328.