L-Glutamic acid-15N

L-Glutamic acid-15N is the 15N-labeled L-Glutamic acid. L-Glutamic acid acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA) . L-Glutamic acid shows a direct activating effect on the release of DA from dopaminergic terminals[1].

Product Specifications

CAS Number

[21160-87-2]

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Endogenous Metabolite; Ferroptosis; iGluR

Type

Isotope-Labeled Compounds

Related Pathways

Apoptosis; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/l-glutamic-acid-15n.html

Purity

98.0

Solubility

H2O : 5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

OC(CC[C@H]([15NH2])C(O)=O)=O

Molecular Formula

C5H9 15NO4

Molecular Weight

148.12

Precautions

H302, H315, H319, H335

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Giorguieff MF, et al. Presynaptic effect of L-glutamic acid on the release of dopamine in rat striatal slices. Neurosci Lett. 1977 Oct;6 (1) :73-7.