FABP4/5-IN-6
FABP4/5-IN-6 is an orally active, potent FABP4/5 inhibitor (Ki = 0.41/2.53 μM), showing low selectivity over FABP3 (Ki = 59.72 μM) . FABP4/5-IN-6 inhibits the secretion of MCP-1 and IL-6 in Lipopolysaccharides (HY-D1056) (LPS) -induced THP-1 macrophage. FABP4/5-IN-6 exhibits significant anti-inflammatory effects and attenuates LPS-induced liver injury. FABP4/5-IN-6 has low hERG inhibition (LD50 > 2000 mg/kg) . FABP4/5-IN-6 can be used for the study of Inflammation-related diseases[1].
Product Specifications
CAS Number
[2975215-64-4]
UNSPSC
12352005
Target
FABP; Interleukin Related
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease; Inflammation/Immunology
Smiles
O=C1C2=CC=C(C=C2C(C3=CC=C(C(Cl)=C3)F)=C(N1C4CCCC4)C(O)=O)Cl
Molecular Formula
C21H16Cl2FNO3
Molecular Weight
420.26
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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