Cordycepin
Nucleoside Antagonist
Product Specifications
Background
Cordycepin is an adenosine analog lacking the hydroxyl at the 3’ position. Inhibits PARP1 and polyadenylation (2). Displays anti-inflammatory effects (1,3) and neuroprotective effects by inhibiting Aβ-induced apoptosis in hippocampal neurons (4). Induces apoptosis in a variety of cancer cell lines (5). Displays antiobesity activity (6).
CAS Number
73-03-0
Product Name Alternative
(2R,3R,5S) -2- (6-Aminopurin-9-yl) -5- (hydroxymethyl) oxolan-3-ol; 3-deoxyadenosine; NSC 63986
UNSPSC
41116105
Type
Antagonist
Source
Synthetic
Field of Research
Cell Signaling | Epigenetics and Nuclear Signaling | Nuclear Signaling Pathways | NFkB Pathway | Neuroscience | Neurodegeneration | Alzheimer's Disease | Cardiovascular System | Heart
Purity
>98% (HPLC) ; NMR (Conforms)
Weight
0.005
Format
White powder
Solubility
May be dissolved in DMSO (25 mg/ml)
Molecular Formula
C10H13N5O3
Molecular Weight
251.2
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. H Kim et al. Mol. Med. 2011 17:893
2. A Kondrashov et al. RNA 2012 18:2236
3. J Yang et al. Biomed. Pharmacother. 2017 95:1777
4. H Song et al. Neurotoxicology 2018 68:73
5. Y Zhang et al. OncoTargets Ther. 2018 11:4479
6. Y Li et al. Curr. Pharm. Des. 2018 Aug. 20, epub
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