MW073
MW073 is a highly selective and orally active 5-HT2BR antagonist (IC50 =70 nM) . MW073 exerts its effects by concentration-dependently inhibiting receptor activity and β-arrestin-1 recruitment. MW073 ameliorates synaptic plasticity and behavioral deficits, including aggression, in Alzheimer’s disease (AD) mouse models. MW073 can be used for Alzheimer’s disease (AD) research[1][2].
Product Specifications
CAS Number
3048608-87-0
UNSPSC
12352005
Target
5-HT Receptor; Arrestin
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Smiles
CN1CCN(CC1)CCNC2=NN=C(C=C2C)C3=CC=C4C=CC=CC4=C3
Molecular Formula
C22H27N5
Molecular Weight
361.48
References & Citations
[1]Roy SM, et al. Optimized 5-HT2b inhibitors for neuropsychiatric syndromes with cognitive dysfunction. Alzheimers Dement (N Y) . 2025 Mar 27;11 (1) :e70073. |[2]Acquarone E, et al. The Highly Selective 5-HT2B Receptor Antagonist MW073 Mitigates Aggressive Behavior in an Alzheimer’s Disease Mouse Model. bioRxiv. 2025.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT2 Receptor
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