OUL312
OUL312 is a potent PARP10 inhibitor (IC50 = 20 nM), showing more than 75-fold greater selectivity for PARP15 (IC50 = 1500 nM) . OUL312 is also at least 18-fold higher than all other human enzymes in the family. OUL312 has a good ADME profile, is able to enter cells, is not toxic, and effectively rescues human cells from PARP10-induced apoptosis at sub-micromolar concentrations. OUL312 can be used for the study of cervical cancer[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; PARP
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics
Field of Research
Cancer; Infection; Inflammation/Immunology
Purity
99.20
Smiles
O=C1NNC(C2=C1C=CC(OCCC3=CC=CC=C3F)=C2)=O
Molecular Formula
C16H13FN2O3
Molecular Weight
300.28
References & Citations
[1]Alaviuhkola J, et al. Optimization of 2,3-dihydrophthalazine-1,4-dione PARP inhibitor scaffold for nanomolar potency and specificity towards human PARP10. Eur J Med Chem. 2025 Dec 15;300:118111.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PARP10
Available Sizes
More Discoveries
Explore Other Products
Browse additional items from our catalog
LV665876 1.0 µg DNA
HRG Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV-C-term-HA)
Sign In for Pricing
View Details 
NBP3-08910JF549 100 µL
Rabbit Monoclonal CD45 Antibody (PTPRC/1975R) [Janelia Fluor 549]
Sign In for Pricing
View Details TRC-O850130-500MG 500 mg
2-Oxo-2,3-dihydro-4-benzoxazole Carboxylic Acid
Sign In for Pricing
View Details