PARP1-IN-46

PARP1-IN-46 is a potent PARP-1 inhibitor with an IC50 of 2.4 nM. PARP1-IN-46 demonstrates remarkable anti-proliferative activity in both rat (C6) and human (U87MG) glioma cells. PARP1-IN-46 promotes PARP cleavage, triggers DNA damage, and increases ROS. PARP1-IN-46 effectively inhibits the migration, invasion and colony formation of glioma cells, and ultimately induces cell apoptosis. PARP1-IN-46 can be used to the study of glioma[1].

Product Specifications

CAS Number

[2505146-00-7]

UNSPSC

12352005

Target

Apoptosis; DNA/RNA Synthesis; PARP; Reactive Oxygen Species (ROS)

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Field of Research

Cancer

Smiles

O=C(C(C1=CC(OC)=CC=C12)=C3NC2=O)C4=C(C3=O)C=CC=C4

Molecular Formula

C18H11NO4

Molecular Weight

305.28

References & Citations

[1]Pathi VB, et al. Isoquinolinone-Naphthoquinone Hybrids as Potent PARP-1 Inhibitors Induce Apoptosis in Glioma via DNA Damage and ROS Generation. J Med Chem. 2025 Sep 25;68 (18) :19153-19168.