KWZY-11
KWZY-11 (Compound 11) is a potent PARP/CDK6 dual inhibitor with IC50 values of 156.8, 197.3, and 13.3 nM for PARP1, PARP2, and CDK6, respectively. KWZY-11 inhibits tumor cell proliferation by regulating the Wnt/β-catenin signaling pathway. KWZY-11 induces excessive DNA damage and apoptosis in MDA-MB-231 breast cancer cells[1].
Product Specifications
UNSPSC
12352211
Target
Apoptosis; CDK; PARP; Wnt; β-catenin
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Stem Cell/Wnt
Field of Research
Cancer
Smiles
O=C(C1=CC2=CN=C(N=C2N1C3CCCC3)NC4=C(C=C(C=C4)C5=NC6=C(N5)C=CC=C6C(N)=O)Cl)N(C)C
Molecular Formula
C28H27ClN8O2
Molecular Weight
543.02
References & Citations
[1]Zhang Y, et al. Design and Synthesis of PARP/CDK6 Dual-Target Inhibitors Modulating of Wnt/β-Catenin Signaling Pathway for the Treatment of BRCA Wild-Type TNBC. J Med Chem. 2025 Jun 10.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK6; PARP1; PARP2
Curated Selection
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