2'-Deoxyadenosine monohydrate-3′-13C

2'-Deoxyadenosine monohydrate-3′-13C is the 13C labeled 2'-Deoxyadenosine monohydrate (HY-W011683) [1]caspase-3 and promotes apoptosis. 2'-Deoxyadenosine monohydrate inhibits the activity of S-adenosyl-L-homocysteine hydrolase (SAHH) . 2'-Deoxyadenosine monohydrate inhibits the growth of various cells. 2'-Deoxyadenosine monohydrate has an anticancer effect on colon cancer>[2][3][4]</sup.

Product Specifications

UNSPSC

12352005

Target

Apoptosis; Caspase; Endogenous Metabolite; Isotope-Labeled Compounds; Nucleoside Antimetabolite/Analog

Type

Isotope-Labeled Compounds

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Others

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Endocrinology; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/2-deoxyadenosine-monohydrate-3-13c.html

Solubility

10 mM in DMSO

Smiles

NC1=NC=NC2=C1N=CN2[C@@H]3O[C@H](CO)[13C@@H](O)C3.O

Molecular Formula

C9 13CH15N5O4

Molecular Weight

270.25

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Iain L. Campbell, et al. Effects of adenosine, 2-deoxyadenosine and N6-phenylisopropyladenosine on rat islet function and metabolism. Biochem J (1982) 204 (3) : 689-696.|[3]Giannecchini M, et al. 2'-Deoxyadenosine causes apoptotic cell death in a human colon carcinoma cell line. J Biochem Mol Toxicol. 2003;17 (6) :329-37.|[4]Cass CE, et al. Effects of 2'-deoxyadenosine, 9-beta-D-arabinofuranosyladenine, and related compounds on S-adenosyl-L-homocysteine hydrolase activity in synchronous and asynchronous cultured cells. Cancer Res. 1982 Dec;42 (12) :4991-8.