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BTK-IN-44

BTK-IN-44 (Compound 10) is a potent noncovalent inhibitor of Bruton’s tyrosine kinase (BTK) with an IC50 value of 24.7 nM. BTK-IN-44 interferes with signaling pathways of B cell malignancies, showing antitumor effects in lymphoma cells. BTK-IN-44 is promising for research of B cell malignancies (such as lymphoma) [1].

Product Specifications

UNSPSC

12352005

Target

Btk

Related Pathways

Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Smiles

CC1=C(NC(C2=CC3=C(C=CC=C3)N2)=O)C=CC=C1C4=CC=C5C(NC6=CC(C(O)(C)C)=CC=C6N54)=O

Molecular Formula

C30H26N4O3

Molecular Weight

490.55

References & Citations

[1]Tian C, et al. Structure-based design of novel pyrrolo[1,2-a]quinoxalin-4 (5H) -one derivatives as potent noncovalent Bruton's tyrosine kinase (BTK) inhibitors. Bioorg Med Chem Lett. 2025 Sep 1;125-126:130285.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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