E-4031
Herg channel blocker
Product Specifications
Background
E-4031 acts on a specific class of voltage gated potassium channels, the hERG channels. It does this by binding to the open channels, although its structural target is unclear (1-4). It is also an anti-arrhythmic drug (5).
CAS Number
113558-89-7
Product Name Alternative
N-[4-[[1-[2- (6-Methyl-2-pyridinyl) ethyl]-4-piperidinyl]carbonyl]phenyl]methanesulfonamide dihydrochloride, dihydrate
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Neuroscience | Ion Channels
Purity
>98% (TLC: CH2Cl2/CH3OH; 9:1 with 1% NH4OH; Silica gel 60; Rf=0.39) ; NMR conforms
Weight
0.01
Format
White solid
Solubility
Soluble in water (100 mg/ml) and warm DMSO (25 mg/ml)
Molecular Formula
C₂₁H₂₇N₃O₃S · 2HCl · 2H₂O
Molecular Weight
510.5
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Gerlach A.C., Stoehr S.J., Castle N.A. (2010) Mol Pharmacol. 77(1): 56-68.
2. Perrin M.J., et al. (2008) Prog Biophys Mol Biol. 98: 137-148.
3. Sanguinetti M.C., Jurkiewicz N.K. (1990) J Gen Physiol. 96: 195-215.
4. Spector P.S., Curran M.E., Keating M.T., and Sanguinetti M.C. (1996) Circ Res. 78: 499-503.
5. Miyake K., et al. (1990) J Med Chem. 33: 903.
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