U-46619 Glycine methyl ester

U-46619 Glycine methyl ester has a modification at the C-1 position of U-46619, which uniquely alter its binding properties to the TP receptor or any of the PGH2-metabolizing enzymes. U-46619 is a stable analog of the endoperoxide PGH2. U-46619 is also an agonist of TP receptor. U-46619 can change the shape of platelet, aggregation and contraction of vascular smooth muscle. U-46619 Glycine methyl ester can be studied in research to explore the inhibition of various enzymes in the arachidonic acid metabolic pathway. U-46619 Glycine methyl ester can also act as a lipophilic prodrug form of U-46619 that alters its distribution and pharmacokinetic properties[1][2][3][4].

Product Specifications

UNSPSC

12352211

Target

Prostaglandin Receptor

Related Pathways

GPCR/G Protein

Field of Research

Others

Smiles

CCCCCC(/C=C/[C@H]1C2OCC(C1C/C=C\CCCC(NCC(OC)=O)=O)C2)O

Molecular Formula

C24H39NO5

Molecular Weight

421.57

References & Citations

[1]Abramovitz M, et al., The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim Biophys Acta. 2000 Jan 17;1483 (2) :285-93. |[2]Coleman RA, et al., Comparison of the actions of U-46619, a prostaglandin H2-analogue, with those of prostaglandin H2 and thromboxane A2 on some isolated smooth muscle preparations. Br J Pharmacol. 1981 Jul;73 (3) :773-8.|[3]Liel N, et al., Binding of a thromboxane A2/prostaglandin H2 agonist [3H]U46619 to washed human platelets. Prostaglandins. 1987 Jun;33 (6) :789-97.|[4]Tymkewycz PM, et al., Heterogeneity of thromboxane A2 (TP-) receptors: evidence from antagonist but not agonist potency measurements. Br J Pharmacol. 1991 Mar;102 (3) :607-14.