ITGB3-IN-1
ITGB3-IN-1 is an orally active integrin subunit beta 3 ITGB3 inhibitor with a Kd of 7.26 μM. ITGB3-IN-1 exhibits potent anti-orthopoxvirus effects with an EC50 for vaccinia virus (VACV) of 1.82 μM. ITGB3-IN-1 inhibits hERG with an IC50 of 1.13 μM. ITGB3-IN-1 can be used for the study of orthopoxvirus[1].
Product Specifications
UNSPSC
12352100
Target
Integrin; Orthopoxvirus; Potassium Channel
Related Pathways
Anti-infection; Cytoskeleton; Membrane Transporter/Ion Channel
Applications
COVID-19-anti-virus
Field of Research
Infection
Purity
98.69
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
COC1=CC=C(C=C1OC)/C=C/C(NC2=C(C=CC=C2)C(OCCC(C)C)=O)=O
Molecular Formula
C23H27NO5
Molecular Weight
397.46
References & Citations
[1]Xu M, et al. A dual-view deep learning-driven discovery of cinnamoyl anthranilic acid derivatives against orthopoxvirus through targeting host ITGB3. Eur J Med Chem. 2025 Nov 15;298:118002.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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