BChE/MAO-B-IN-2
BChE/MAO-B-IN-2 is a dual inhibitor of BChE (IC50 = 0.05 μM, Ki = 0.01 μM) and MAO-B (IC50 = 0.45 μM, Ki = 0.08 μM) with good blood-brain barrier permeability. BChE/MAO-B-IN-2 exhibits antioxidant activity, including DPPH radical scavenging, CUPRAC copper ion reduction, and superoxide anion scavenging. BChE/MAO-B-IN-2 can be used for the study of Alzheimer's disease (AD) [1].
Product Specifications
UNSPSC
12352005
Target
Cholinesterase (ChE) ; Monoamine Oxidase
Related Pathways
Neuronal Signaling
Field of Research
Neurological Disease
Smiles
C#CCN[C@H](C1=CC(OC(N2CCCCC2)=O)=CC=C1)C
Molecular Formula
C17H22N2O2
Molecular Weight
286.37
References & Citations
[1]Teke Tuncel S, et al. Multitarget-directed carbamate and carbamothioate derivatives: Cholinesterase and monoamine oxidase inhibition, anti-β-amyloid (Aβ) aggregation, antioxidant and blood-brain barrier permeation properties against Alzheimer's disease. Eur J Med Chem. 2025 Nov 15;298:117986.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AChE; BChE; MAO-A; MAO-B
Curated Selection
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