P-SCN-Bn-NOTA (trihydrochloride)

P-SCN-Bn-NOTA trihydrochloride is a macrocyclic chelator. p-SCN-Bn-NOTA trihydrochloride can be covalently coupled to molecules such as peptides through the thiocyanate group to form hexacoordinate copper (such as 64Cu) complexes. p-SCN-Bn-NOTA trihydrochloride specifically binds to GRPR or EGFR highly expressed on the surface of tumor cells, mediating tumor enrichment of radioactive probes. p-SCN-Bn-NOTA trihydrochloride can be used to study malignant tumors expressing GRPR or EGFR, such as prostate cancer and colorectal cancer[1][2].

Product Specifications

CAS Number

[1583289-85-3]

UNSPSC

12352200

Hazard Statement

H302, H315, H319, H335

Target

Biochemical Assay Reagents; Bombesin Receptor; EGFR; Radionuclide-Drug Conjugates (RDCs)

Type

Biochemical Assay Reagents

Related Pathways

Antibody-drug Conjugate/ADC Related; GPCR/G Protein; JAK/STAT Signaling; Others; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/p-scn-bn-nota-trihydrochloride.html

Purity

99.62

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C(O)CN1C(CC2=CC=C(N=C=S)C=C2)CN(CC(O)=O)CCN(CC(O)=O)CC1.Cl.Cl.Cl

Molecular Formula

C20H29Cl3N4O6S

Molecular Weight

559.89

Precautions

H302, H315, H319, H335

References & Citations

[1]Craft JM, et al. In vitro and in vivo evaluation of a 64Cu-labeled NOTA-Bn-SCN-Aoc-bombesin analogue in gastrin-releasing peptide receptor expressing prostate cancer. Nucl Med Biol. 2012 Jul;39 (5) :609-16.|[2]Yun M, et al. A High-Affinity Repebody for Molecular Imaging of EGFR-Expressing Malignant Tumors. Theranostics. 2017 Jun 25;7 (10) :2620-2633.