PDIA1-IN-1
PDIA1-IN-1 is a protein disulfide isomerase 1 (PDIA1) inhibitor. PDIA1-IN-1 can inhibit NLRP3 inflammasome assembly and activity, with an IC50 value of 1 μM. PDIA1-IN-1 can reduce IL-1β secretion. PDIA1-IN-1 can be used for the researches of inflammation and neurological disease[1].
Product Specifications
UNSPSC
12352100
Target
Interleukin Related; PDI
Related Pathways
Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease
Field of Research
Inflammation/Immunology; Neurological Disease
Smiles
C#CCCNC([C@@H](NC([C@@H](NC(OC(C)(C)C)=O)CC1=CC=CC=C1)=O)CC2=CC=C(C=C2)OS(=O)(C=C)=O)=O
Molecular Formula
C29H35N3O7S
Molecular Weight
569.67
References & Citations
[1]Buasakdi C, et al. Optimizing PDIA1 Inhibition as a Strategy to Inhibit NLRP3 Inflammasome Activation and Activity. ACS Chem Biol. 2025 Aug 15;20 (8) :1892-1901.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IL-1
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