PDIA1-IN-1

PDIA1-IN-1 is a protein disulfide isomerase 1 (PDIA1) inhibitor. PDIA1-IN-1 can inhibit NLRP3 inflammasome assembly and activity, with an IC50 value of 1 μM. PDIA1-IN-1 can reduce IL-1β secretion. PDIA1-IN-1 can be used for the researches of inflammation and neurological disease[1].

Product Specifications

UNSPSC

12352100

Target

Interleukin Related; PDI

Related Pathways

Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease

Field of Research

Inflammation/Immunology; Neurological Disease

Smiles

C#CCCNC([C@@H](NC([C@@H](NC(OC(C)(C)C)=O)CC1=CC=CC=C1)=O)CC2=CC=C(C=C2)OS(=O)(C=C)=O)=O

Molecular Formula

C29H35N3O7S

Molecular Weight

569.67

References & Citations

[1]Buasakdi C, et al. Optimizing PDIA1 Inhibition as a Strategy to Inhibit NLRP3 Inflammasome Activation and Activity. ACS Chem Biol. 2025 Aug 15;20 (8) :1892-1901.