TH16

TH16 is an antibacterial agent (MIC=2 μg/mL against methicillin-resistant Staphylococcus aureus, MRSA) . TH16 disrupts bacterial cytoplasmic membrane integrity, elevating intracellular reactive oxygen species (ROS) levels to induce bacterial death. TH16 is promising for research of bacterial infection[1].

Product Specifications

UNSPSC

12352005

Target

Bacterial; Reactive Oxygen Species (ROS)

Related Pathways

Anti-infection; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Field of Research

Infection

Smiles

C=CCC1=CC=C(C(C2=CC=C(C(CC=C)=C2)O)=C1)OC(CCCCC[P+](C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5)=O.[Br-]

Molecular Formula

C42H42BrO3P

Molecular Weight

705.66

References & Citations

[1]Feng J, et al. Development of TPP-HK conjugates as membrane-targeting antibacterial agents against methicillin-resistant Staphylococcus aureus. Bioorg Chem. 2025 Aug;163:108758.