Lck degrader-1
Lck degrader-1 (Compound 17) is a molecular glue degrader targeting lymphocyte-specific protein tyrosine kinase (LCK) (DC50=23.1 nM) . Lck degrader-1 is promising for research of T-cell acute lymphoblastic leukemia (T-ALL) [1].
Product Specifications
CAS Number
3095033-62-5
UNSPSC
12352005
Target
Molecular Glues; Src
Related Pathways
PROTAC; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
CCC1=C(NC2=C1C=CC=C2CN)C(NC3=CC4=C(C(N(C5CCC(NC5=O)=O)C4)=O)C=C3)=O
Molecular Formula
C25H25N5O4
Molecular Weight
459.50
References & Citations
[1]Yoshimura S, et al. LCK-targeting molecular glues overcome resistance to inhibitor-based therapy in T-cell acute lymphoblastic leukemia[J]. bioRxiv, 2025: 2025.07. 03.663042.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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