HexylHIBO (hydrobromide)

HexylHIBO hydrobromide is a potent group I mGluR antagonist with Kbs of 140 μM and 110 μM at mGlu1a and mGlu5a receptors, respectively. HexylHIBO hydrobromide does not inhibits mGlu2 and mGlu4a. HexylHIBO hydrobromide decreases spontaneous excitatory postsynaptic currents (sEPSCs) in rat[1][2].

Product Specifications

UNSPSC

12352005

Target

MGluR

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Neurological Disease

Smiles

O=C1C(CCCCCC)=C(ON1)CC(C(O)=O)N.Br

Molecular Formula

C12H21BrN2O4

Molecular Weight

337.21

References & Citations

[1]Madsen U, et al. Synthesis and pharmacology of 3-isoxazolol amino acids as selective antagonists at group I metabotropic glutamic acid receptors. J Med Chem. 2001;44 (7) :1051-1059. |[2]Bandrowski AE, et al, Prince DA. Baseline glutamate levels affect group I and II mGluRs in layer V pyramidal neurons of rat sensorimotor cortex. J Neurophysiol. 2003;89 (3) :1308-1316.