POI-4
POI-4 is a ligand for METTL3. POI-4 can be used for synthesizing PROTACs such as AF151 (HY-174873) [1].
Product Specifications
UNSPSC
12352005
Target
Ligands for Target Protein for PROTAC; METTL3
Related Pathways
Epigenetics; PROTAC
Field of Research
Cancer
Smiles
O=C(NCC1=CC(NC(CN2CCC(C)(C)CC2)=C3)=C3C=C1)C4=CC(OCC5=CC=CC=C5)=CN=C4
Molecular Formula
C30H34N4O2
Molecular Weight
482.62
References & Citations
[1]Weldert AC, et al. Structure-guided design of a methyltransferase-like 3 (METTL3) proteolysis targeting chimera (PROTAC) incorporating an indole-nicotinamide chemotype. RSC Med Chem. 2025 Jun 19.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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