PX5–9
PX5-9 is an orally active prodrug that can upregulate brain-derived neurotrophic factor (BDNF) . PX5–9 exerts neuroprotective effects by elevating intracellular BDNF levels. PX5-9 can be used for the research of neurodegenerative diseases (such as Alzheimer's disease, Parkinson's disease) and depression, which are associated with reduced BDNF levels[1].
Product Specifications
UNSPSC
12352005
Target
Drug Metabolite
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Smiles
COC1=C(OC2CCCC2)C=CC(/C=C/C(NC3=CC=C([N+](C)([O-])C)C=C3)=O)=C1
Molecular Formula
C23H28N2O4
Molecular Weight
396.48
References & Citations
[1]Zhang Z, et al. Design and characterization of N-oxide cinnamanilide derivative PX5-9: Improved solubility and BDNF upregulation. Bioorg Med Chem Lett. 2025 Sep 1;125-126:130266.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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