Recombinant Bovine TGFBR1 protein (His tag)
Product Specifications
Background
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for TGF-beta.
Abbreviation
TGFBR1
Synonyms
AAT5; ACVRLK 4; ALK 5; Activin A receptor type II like kinase 53kDa; Activin receptor like kinase 5; LDS1A; MSSE; SKR4; Serine/threonine-protein kinase receptor R4; TGF beta Receptor I; TGFR 1; TbetaR-I
UniProt
O46680
Accession Number
O46680
Expression System
E.coli
Tag
N-His
Sequence
Ile 143-Leu 330
Field of Research
Cardiovascular; Signal Transduction; Stem Cells; Cancer; Metabolism; Neuroscience
Endotoxin
< 10 EU/mg of the protein as determined by the LAL method.
Purity
> 95% as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Calculated Molecular Weight
20.6 kDa
Observed Molecular Weight
20 kDa
Species
Bovine
Available Sizes
Frequently Asked Questions
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