CYP1A1-IN-1
CYP1A1-IN-1 (Compound 47) is a small-molecule cytochrome P4501A1 (CYP1A1) inhibitor. CYP1A1-IN-1 reduces the bacterial loads of methicillin-resistant Staphylococcus aureus (MRSA) and Acinetobacter baumannii by enhancing macrophage phagocytosis. CYP1A1-IN-1 is promising for research of sepsis caused by multidrug-resistant (MDR) bacteria[1].
Product Specifications
CAS Number
[3065926-17-9]
UNSPSC
12352005
Target
Bacterial; Cytochrome P450
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Field of Research
Infection; Cardiovascular Disease
Smiles
O=C1N(C2=CC=C(C=C2N1C)C(/C=C/C3=CC=CC=C3C#C)=O)C
Molecular Formula
C20H16N2O2
Molecular Weight
316.35
References & Citations
[1]Wang F, et al. Discovery of CYP1A1 Inhibitors for Host-Directed Therapy against Sepsis. J Med Chem. 2025 Jun 12;68 (11) :11606-11627.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CYP1
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