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Akt1-IN-8

Akt1-IN-8 (Compound JL18) is a potent and oral bioavailable (41%) inhibitor of AKT1 kinase, with an IC50 of 8.8 nM. Akt1-IN-8 exhibits significant antiproliferative effects against PC-3 prostate cancer cells, with an IC50 of 3.0 μM. Akt1-IN-8 can reduce phosphorylated GSK3β levels[1].

Product Specifications

CAS Number

2247688-87-3

UNSPSC

12352005

Target

Akt

Related Pathways

PI3K/Akt/mTOR

Field of Research

Cancer

Smiles

O=C(C(CNC(C)C)C1=CC=C(C=C1)Br)N2CCN(CC2)C3=C4C(Br)=NNC4=NC=N3

Molecular Formula

C21H25Br2N7O

Molecular Weight

551.28

References & Citations

[1]Sun J, et, al. The discovery of novel N-heterocyclic-based AKT inhibitors with potential efficacy against prostate cancer. Eur J Med Chem. 2025 May 5:289:117435.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Akt1

Frequently Asked Questions

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