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5-HT5AR/5-HT6R ligand-1

5-HT5AR/5-HT6R ligand-1 (Compound PP10) is a ligand for serotonin receptors, showing high affinity for 5-HT5A and 5-HT6 receptors, with Ki values of 59 nM and 96 nM, respectively. 5-HT5AR/5-HT6R ligand-1 exhibits certain antiproliferative activity against tumor cells and can be used in the study of cancer[1].

Product Specifications

UNSPSC

12352005

Target

5-HT Receptor

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

O=S(C1=C2C=CC=CC2=CC=C1)(NCCCCCCNC3=NC4=C(C=CC=C4)C(C)N3)=O

Molecular Formula

C25H30N4O2S

Molecular Weight

450.60

References & Citations

[1]Zaręba P, et al. Long-Chain Cyclic Arylguanidines as Multifunctional Serotonin Receptor Ligands with Antiproliferative Activity. ACS Omega. 2025 Feb 11;10 (7) :6446-6469.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

5-HT5 Receptor;5-HT6 Receptor

Frequently Asked Questions

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