5-HT5AR/5-HT6R ligand-1
5-HT5AR/5-HT6R ligand-1 (Compound PP10) is a ligand for serotonin receptors, showing high affinity for 5-HT5A and 5-HT6 receptors, with Ki values of 59 nM and 96 nM, respectively. 5-HT5AR/5-HT6R ligand-1 exhibits certain antiproliferative activity against tumor cells and can be used in the study of cancer[1].
Product Specifications
UNSPSC
12352005
Target
5-HT Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=S(C1=C2C=CC=CC2=CC=C1)(NCCCCCCNC3=NC4=C(C=CC=C4)C(C)N3)=O
Molecular Formula
C25H30N4O2S
Molecular Weight
450.60
References & Citations
[1]Zaręba P, et al. Long-Chain Cyclic Arylguanidines as Multifunctional Serotonin Receptor Ligands with Antiproliferative Activity. ACS Omega. 2025 Feb 11;10 (7) :6446-6469.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT5 Receptor;5-HT6 Receptor
Curated Selection
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