FSP1-IN-1

FSP1-IN-1 (compound 39) is a potent FSP1 inhibitor with an IC50 of 35 nM. FSP1-IN-1 enhances RSL3 (HY-100218A) -induced lipid peroxide accumulation and sensitizes cancer cells to ferroptosis[1].

Product Specifications

UNSPSC

12352005

Target

Ferroptosis

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

COC1=CC=C(C2=NN=C3N2N=C(CN4CCN(C5=CC=C(C(OC)=O)C=C5)CC4)S3)C=C1

Molecular Formula

C23H24N6O3S

Molecular Weight

464.54

References & Citations

[1]Liu W, et al. Design, synthesis and biological evaluation of triazolothiadiazole derivatives as FSP1 inhibitors for sensitizing cancer cells to ferroptosis. Eur J Med Chem. 2025 May 11;293:117737.