NMDA agonist 2

NMDA agonist 2 (compound 8d) is a potent agonist of NMDA receptor, with the EC50 of 0.034 μM for GluN1/2C. NMDA agonist 2 plays an important role in neurological and psychiatric disorders[1].

Product Specifications

UNSPSC

12352005

Target

IGluR

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Smiles

O=C([C@@H](CNC(C1=CC(Br)=C(S1)C2=CC=CC=C2F)=O)N)O

Molecular Formula

C14H12BrFN2O3S

Molecular Weight

387.22

References & Citations

[1]Fabao Zhao, et al. Design of (R) -3- (5-Thienyl) carboxamido-2-aminopropanoic Acid Derivatives as Novel NMDA Receptor Glycine Site Agonists: Variation in Molecular Geometry to Improve Potency and Augment GluN2 Subunit-Specific Activity. J Med Chem. 2025 Jan 23.