VEGFR-2-IN-64
VEGFR-2-IN-64 (Compound 28) is the inhibitor for VEGFR2 with IC50 of 27.8 nM. VEGFR-2-IN-64 inhibits the proliferation of cancer cell A549, T-47D and Caco-2, exhibits anti-migration and anti-cloning activities in cell T-47D, induces apoptosis in T-47D[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; VEGFR
Related Pathways
Apoptosis; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
O=C(OCC1=CN(N=N1)CCCCCCCCCCCCCCCCCC)C2=CC(C(OCC3=CN(N=N3)CCCCCCCCCCCCCCCCCC)=O)=CC(C(OCC4=CN(N=N4)CCCCCCCCCCCCCCCCCC)=O)=C2
Molecular Formula
C72H123N9O6
Molecular Weight
1210.80
References & Citations
[1]Alsehli M, et al., Discovery of novel tris-1,2,3-triazole-based hybrids as VEGFR2 inhibitors with potent anti-proliferative and cytotoxicity through apoptosis induction. Bioorg Chem. 2025 Feb;155:108131.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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