PSMB5 Antibody
Product Specifications
Background
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit in the proteasome. This catalytic subunit is not present in the immunoproteasome and is replaced by catalytic subunit 3i (proteasome beta 8 subunit) . Multiple transcript variants encoding different isoforms have been found for this gene.
NCBI Gene ID
5693
Swiss Prot
P28074
Accession Number
P28074
Host
Rabbit
Reactivity
Human
Immunogen
This PSMB5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 235-263 amino acids from the C-terminal region of human PSMB5.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=57-791
Calculated Molecular Weight
28 kDa
Fragment
Rabbit Ig
Symbol
PSMB5
NCBI Official Name
Proteasome subunit beta type-5
NCBI Organism
Homo sapiens
Background Reference 01
Ri, M., et al. Leukemia 24 (8) :1506-1512 (2010)
Background Reference 02
Lu, S., et al. Exp. Hematol. 37 (7) :831-837 (2009)
Background Reference 03
Lu, S., et al. Exp. Hematol. 36 (10) :1278-1284 (2008)
Background Reference 04
Oerlemans, R., et al. Blood 112 (6) :2489-2499 (2008)
Other Product Names
Proteasome subunit beta type-5, Macropain epsilon chain, Multicatalytic endopeptidase complex epsilon chain, Proteasome chain 6, Proteasome epsilon chain, Proteasome subunit MB1, Proteasome subunit X, PSMB5, LMPX, MB1, X
Tested Applications
WB, IHC-P
Protein ID
187608890
Physical Properties
Liquid
Curated Selection
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