Autophagy agonist-1
Autophagy agonist-1 (compound 22) is an Autophagy agonist. Autophagy agonist-1 exhibits significant anticancer activity against HepG2 cells and normal cells with IC50s of 8.8 μM and > 50 μM. Autophagy agonist-1 induces G1/S phase cell cycle arrest and inhibits CDK4 and CyclinD1 expression while upregulating P21. Autophagy agonist-1 promotes the accumulation of autophagosomes and the proteins LC3 and PINK1, enhancing autophagy and mitophagy in HepG2 cells[1].
Product Specifications
UNSPSC
12352005
Target
Atg8/LC3; Autophagy; CDK; PINK1/Parkin
Related Pathways
Autophagy; Cell Cycle/DNA Damage; Neuronal Signaling
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
O=C1C2[C@@]3([H])[C@@](C3(C)C)([H])C[C@@H](C)[C@@](C=C(C)[C@@H]4OCC5=NN=C(/C=C/C6=CC=C(N(C)C)C=C6)O5)1[C@]4(O)[C@H](O)C(C)=C2
Molecular Formula
C33H41N3O5
Molecular Weight
559.70
References & Citations
[1]Liu Z, et al. 20-Deoxyingenol ester and ether derivatives: Synthesis, properties and cytotoxicity. Bioorg Chem. 2025 Mar;156:108207.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK4
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