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HAChE-IN-10

HAChE-IN-10 (Compound ET11) is the inhibitor for human acetylcholinesterase (AChE) with an IC50 of 6.34 nM. hAChE-IN-10 scavenges free radicals, and exhibits antioxidant activity. hAChE-IN-10 exhibits metal chelating activity, inhibits Cu2+-induced Aβ1-42 aggregation, reduces the formation of amyloid plaques, and exhibits neuroprotective activity. hAChE-IN-10 ameliorates the Scopolamine -induced cognitive impairment in mouse models[1].

Product Specifications

CAS Number

3058182-98-9

UNSPSC

12352005

Target

Amyloid-β; Cholinesterase (ChE)

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Smiles

O=C(C1=NN(C2=NC=C(C=C2)F)C(O)=C1)NCCCNC3=C(CCCC4)C4=NC5=C3C=CC(Cl)=C5

Molecular Formula

C25H24ClFN6O2

Molecular Weight

494.95

References & Citations

[1]Wang H, et al., Design, synthesis and biological evaluation of novel pyrazolinone derivatives as multifunctional ligands for the treatment of Alzheimer's disease. Bioorg Chem. 2025 Jan;154:108052.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

AChE

Frequently Asked Questions

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