Chaetocin
Methyltransferase inhibitor
Product Specifications
Background
Inhibits the lysine methyltransferase SU (VAR)3-9. Displays antimyeloma activity in IL-6-dependent myeloma cell lines. Cell permeable.
CAS Number
28097-03-2
Product Name Alternative
2, 2', 3S, 3'S, 5aR, 5'aR, 6, 6'-octahydro-3, 3'-bis (hydroxymethyl) -2, 2'-dimethyl-[10bR, 10'bR (11aS, 11'aS) -bi-3, 11a-epidithio-11aH-pyrazino[1', 2':1, 5]pyrrolo[2, 3-b]indole]-1, 1', 4, 4'-tetrone
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cell Signaling | Epigenetics and Nuclear Signaling | Cancer
Purity
>99% (TLC), NMR conforms
Weight
0.0002
Format
Lyophilized Solid
Solubility
Soluble in 25 mg/ml DMSO or 25 mg/ml Ethanol
Molecular Formula
C30H28N6O6S4
Molecular Weight
696.9
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Greiner D., et al. (2005) Nat Chem Biol. 1: 143. 2. Isham, C.R., et al. (2007) Blood. 109: 2579.
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