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Aromatase-IN-4

Aromatase-IN-4 (Compound 6a) is an aromatase (Aromatase) inhibitor. Aromatase-IN-4 exhibits anticancer activity, with GI50 values of 2.95 μM, 3.35 μM, 2.27 μM, 8.46 nM, and 1.56 μM against the MDAMB-231, MCF-7, A-549, NCI-H23, and A-498 cell lines, respectively[1]. Aromatase-IN-4 effectively blocks aromatase-dependent estrogen production[1].

Product Specifications

CAS Number

3060588-16-8

UNSPSC

12352005

Target

Cytochrome P450

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Endocrinology

Smiles

C1(NC2=NC=C(NC3=CC=C(C4=NC5=C(N4)C=CC=C5)C=C3)C=C2)=CC=CN=C1

Molecular Formula

C23H18N6

Molecular Weight

378.43

References & Citations

[1]Sabale P, et al. Molecular Docking, Synthesis and Biological Evaluation of New Benzimidazole‐Pyridine Derivatives as Potential Aromatase Inhibitor for the Treatment of Cancer[J]. ChemistrySelect, 2024, 9 (37) : e202401797.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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