Aromatase-IN-4
Aromatase-IN-4 (Compound 6a) is an aromatase (Aromatase) inhibitor. Aromatase-IN-4 exhibits anticancer activity, with GI50 values of 2.95 μM, 3.35 μM, 2.27 μM, 8.46 nM, and 1.56 μM against the MDAMB-231, MCF-7, A-549, NCI-H23, and A-498 cell lines, respectively[1]. Aromatase-IN-4 effectively blocks aromatase-dependent estrogen production[1].
Product Specifications
CAS Number
[3060588-16-8]
UNSPSC
12352005
Target
Cytochrome P450
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Endocrinology
Smiles
C1(NC2=NC=C(NC3=CC=C(C4=NC5=C(N4)C=CC=C5)C=C3)C=C2)=CC=CN=C1
Molecular Formula
C23H18N6
Molecular Weight
378.43
References & Citations
[1]Sabale P, et al. Molecular Docking, Synthesis and Biological Evaluation of New Benzimidazole‐Pyridine Derivatives as Potential Aromatase Inhibitor for the Treatment of Cancer[J]. ChemistrySelect, 2024, 9 (37) : e202401797.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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