HCAII/XII-IN-1

HCAII/XII-IN-1 (compound 4l) is a potent inhibitor of hCAXII and hCAII, with Kis of 8.4 and 9.4 nM, respectively. hCAXII-IN-11 plays an important role in cancer research[1].

Product Specifications

UNSPSC

12352211

Target

Carbonic Anhydrase

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cancer

Smiles

OC1=CC=CC=C1C(C=C(NC2=CC(S(=O)(N)=O)=CC=C2)C3=O)N3C4=CC(S(=O)(N)=O)=CC=C4

Molecular Formula

C22H20N4O6S2

Molecular Weight

500.55

References & Citations

[1]Cristina M Al-Matarneh, et al. Novel 3-Sulfonamide Dual-Tail Pyrrol-2-one Bridged Molecules as Potent Human Carbonic Anhydrase Isoform Inhibitors: Design, Synthesis, Molecular Modeling Investigation, and Anticancer Activity in MeWo, SK-BR-3, and MG-63 Cell Lines. J Med Chem. 2025 Jan 10. doi: 10.1021/acs.jmedchem.4c02586.