PROTAC K-Ras Degrader-2
PROTAC K-Ras degrader-2 (compound 48) is a pan-KRAS-mutant PROTAC degrader with an IC50 of ≤200 nM for KRAS G12V/RAF1. PROTAC K-Ras degrader-2 degrades SW620 KRAS G12D with a DC50 of ≤200 nM. PROTAC K-Ras degrader-2 inhibits cell growth of SW620 3D cell with an IC50 of ≤20 nM. (Pink: KRAS inhibitor-30 (HY-164366) ) [1].
Product Specifications
CAS Number
[3043670-74-9]
UNSPSC
12352005
Target
PROTACs; Ras
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway; PROTAC
Field of Research
Cancer
Smiles
FC1=C(C2=CC(O)=CC3=C2C(CC)=C(F)C=C3)N=CC4=C1N=C(N=C4N5C[C@](O)(CCC5)C)OCC6(CC6)CN7CCC(C)(CC7)CN8CCN(C9=CC(F)=C(C%10C(NC(CC%10)=O)=O)C(F)=C9)CC8
Molecular Formula
C52H60F4N8O5
Molecular Weight
953.08
References & Citations
[1]Robert Luo, et al. Glutarimide-containing pan-kras-mutant degrader compounds and uses thereof. WO2024118966A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
K-Ras
Available Sizes
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