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Z218484536

Z218484536 is a selective and brain-penetrant phosphoserine phosphatase (PSPH) inhibitor. Z218484536 binds to PSPH with a Kd value of approximately 0.23 μM. Z218484536 reduces L-serine and D-serine levels in astrocytes. Z218484536 is able to suppress spontaneous epileptic seizures without causing serious side effects. Z218484536 also shows good anti-epileptic effects in the temporal lobe epilepsy (TLE) model[1].

Product Specifications

CAS Number

1223877-07-3

UNSPSC

12352005

Target

Phosphatase

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Concentration

10mM

Purity

97.65

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(N/N=C/C1=CNN=C1C2=CC=C(F)C=C2)N

Molecular Formula

C11H10FN5O

Molecular Weight

247.23

References & Citations

[1]Sha L, et al. Pharmacological inhibition of PSPH reduces serine levels and epileptic seizures. Nat Chem Biol. 2025 Jun 2.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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