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Sodium Valproate

HDAC inhibitor

Product Specifications

Background

Histone deacetylase inhibitor (IC50=400 µM). Demonstrates neuroprotective, anticancer and anti-inflammatory activity. Inhibits Aβ production and neuritic plaque formation in Alzheimer's mouse models. Clinically useful anticonvulsant.

Product Name Alternative

2-Propylpentanoic acid Na

UNSPSC

41116105

Source

Synthetic

Purity

>98% (TLC), NMR conforms

Weight

Format

White Solid

Solubility

Soluble in 50 mg/ml Water

Molecular Formula

C8H15NaO2

Molecular Weight

166.2

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Phiel C.J., et al. (2001) J. Biol. Chem. 276: 36734. 2. Kim H.J., et al. (2007) J. Pharmacol. Exp. Ther. 321: 892. 3. Qing H., et al. (2008) J. Exp. Med. 205: 2781.